Association between CD209 -336A/G and -871A/G Polymorphisms and Susceptibility of Tuberculosis: A Meta-Analysis

BACKGROUND The association between CD209 promoter polymorphisms (-336A/G, -871A/G) and tuberculosis (TB) risk has been widely reported, but results of previous studies remain controversial and ambiguous. To assess the association between CD209 polymorphisms and TB risk, a meta-analysis was performed. METHODS Based on comprehensive searches of the PubMed, Embase, Web of Science, Weipu, and CBM databases, we identified outcome data from all articles estimating the association between CD209 polymorphisms and TB risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated. RESULTS A total of 14 studies with 3,610 cases and 3,539 controls were identified. There was no significant association between CD209 -336A/G polymorphism and TB risk (OR = 1.04, 95% CI = 0.91-1.19 for G vs. A; OR = 1.13, 95% CI = 0.84-1.53 for GG vs. AA; OR = 1.04, 95% CI = 0.87-1.24 for GG+AG vs. AA; OR = 1.11, 95% CI = 0.88-1.39 for GG vs. AG+AA). However, the significant association was revealed for Asians in GG vs. AA (OR = 2.48, 95% CI = 1.46-4.22, P = 0.0008) and GG vs. AG+AA (OR = 2.10, 95% CI = 1.33-3.32, P = 0.001). For the CD209 -871A/G polymorphism, lack of an association was also found (OR = 0.81, 95% CI = 0.70-0.95 for G vs. A; OR = 1.00, 95% CI = 0.52-1.93 for GG vs. AA; OR = 0.73, 95% CI = 0.60-0.89 for GG+AG vs. AA; OR = 1.09, 95% CI = 0.57-2.10 for GG vs. AG+AA). CONCLUSION The present meta-analysis suggested that CD209 promoter polymorphisms (-336A/G, -871A/G) were unlikely to substantially contribute to TB susceptibility. However, the GG genotype of CD209 -336A/G polymorphism might be a genetic risk factor that increases TB susceptibility for Asians in GG vs. AA and GG vs. AG+AA.